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Antibacterial Activity of Rationally Designed Antimicrobial Peptides by Tincho, Marius B.; Morris, Thureyah; Meyer, Mervin; Pretorius, Ashley is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Antibacterial Activity of Rationally Designed Antimicrobial Peptides about?

Many infectious diseases are still prevalent in the world's populations since no effective treatments are available to eradicate them. The reasons may either be the antibiotic resistance towards the available therapeutic molecules or the slow rate of producing adequate therapeutic regimens to tackle the rapid growth of new infectious diseases, as well as the toxicity of current treatment regimens. Due to these reasons, there is a need to seek and develop novel therapeutic regimens to reduce the rapid scale of bacterial infections. Antimicrobial Peptides (AMPs) are components of the first line of defense for prokaryotes and eukaryotes and have a wide range of activities against Gram-negative and Gram-positive bacteria, fungi, cancer cells, and protozoa, as well as viruses. In this study, peptides which were initially identified for their HIV inhibitory activity were further screened for antibacterial activity through determination of their kinetics as well as their cytotoxicity. From the results obtained, the MICs of two AMPs (Molecule 3 and Molecule 7) were 12.5 __μ__g/ml for __K. pneumoniae__ (ATCC 700603) and 6.25 __μ__g/ml for __P__. __aeruginosa__ (ATCC 22108). The two AMPs kil

Who reads Antibacterial Activity of Rationally Designed Antimicrobial Peptides?

Author

Tincho, Marius B.; Morris, Thureyah; Meyer, Mervin; Pretorius, Ashley

Publisher

Hindawi Limited; Hindawi Publishing Corporation; New York NY: Hindawi Pub. Corp., 2009-; London: Hindawi (ISSN 1687-918X)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)