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Comparison of the virulence of exopolysaccharide-producing Prevotella intermedia to exopolysaccharide non-producing periodontopathic organisms by Takeshi Yamanaka; Kazuyoshi Yamane; Tomoyo Furukawa; Chiho Matsumoto-Mashimo; Chieko Sugimori; Takayuki Nambu; Noboru Obata; Clay B Walker; Kai-Poon Leung; Hisanori Fukushima is a Medicine article available to read on EtoBox.
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## Background Evidence in the literature suggests that exopolysaccharides (EPS) produced by bacterial cells are essential for the expression of virulence in these organisms. Secreted EPSs form the framework in which microbial biofilms are built. ## Methods This study evaluates the role of EPS in __Prevotella intermedia__ for the expression of virulence. This evaluation was accomplished by comparing EPS-producing __P. intermedia__ strains 17 and OD1-16 with non-producing __P. intermedia__ ATCC 25611 and __Porphyromonas gingivalis__ strains ATCC 33277, 381 and W83 for their ability to induce abscess formation in mice and evade phagocytosis. ## Results EPS-producing __P. intermedia__ strains 17 and OD1-16 induced highly noticeable abscess lesions in mice at 10^7^ colony-forming units (CFU). In comparison, __P. intermedia__ ATCC 25611 and __P. gingivalis__ ATCC 33277, 381 and W83, which all lacked the ability to produce viscous materials, required 100-fold more bacteria (10^9^ CFU) in order to induce detectable abscess lesions in mice. Regarding antiphagocytic activity, __P. intermedia__ strains 17 and OD1-16 were rarely internalized by human polymorphonuclear leukocytes, but other str
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- Author
- Takeshi Yamanaka; Kazuyoshi Yamane; Tomoyo Furukawa; Chiho Matsumoto-Mashimo; Chieko Sugimori; Takayuki Nambu; Noboru Obata; Clay B Walker; Kai-Poon Leung; Hisanori Fukushima
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)