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Assessment of the causal relationship between gut microbiota and cardiovascular diseases: a bidirectional Mendelian randomization analysis by Xiao-Ce Dai; Yi Yu; Si-Yu Zhou; Shuo Yu; Mei-Xiang Xiang; Hong Ma is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Assessment of the causal relationship between gut microbiota and cardiovascular diseases: a bidirectional Mendelian randomization analysis about?

## Background Previous studies have shown an association between gut microbiota and cardiovascular diseases (CVDs). However, the underlying causal relationship remains unclear. This study aims to elucidate the causal relationship between gut microbiota and CVDs and to explore the pathogenic role of gut microbiota in CVDs. ## Methods In this two-sample Mendelian randomization study, we used genetic instruments from publicly available genome-wide association studies, including single-nucleotide polymorphisms (SNPs) associated with gut microbiota (__n__ = 14,306) and CVDs (__n__ = 2,207,591). We employed multiple statistical analysis methods, including inverse variance weighting, MR Egger, weighted median, MR pleiotropic residuals and outliers, and the leave-one-out method, to estimate the causal relationship between gut microbiota and CVDs. Additionally, we conducted multiple analyses to assess horizontal pleiotropy and heterogeneity. ## Results GWAS summary data were available from a pooled sample of 2,221,897 adult and adolescent participants. Our findings indicated that specific gut microbiota had either protective or detrimental effects on CVDs. Notably, Howardella (OR = 0.955, 9

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Author

Xiao-Ce Dai; Yi Yu; Si-Yu Zhou; Shuo Yu; Mei-Xiang Xiang; Hong Ma

Publisher

BioMed Central

Published

2024

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)