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Can I read RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway on EtoBox?
RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway by Qingwen Zhu; Xinyu Zhang; Fei Lu; Siyu Miao; Chunyang Zhang; Zhenzhen Liu; Zejun Gao; Meihao Qi; Xiaogang An; Panling Geng; Sufang Wang; Hongbo Ren; Fugen Han; Ruyue Zhang; DingJun Zha is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway about?
## Background Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors of the head and neck. Vasculogenic mimicry (VM) is crucial for tumor growth and metastasis and refers to the formation of fluid channels by invasive tumor cells rather than endothelial cells. However, the regulatory mechanisms underlying VM during the malignant progression of LSCC remain largely unknown. ## Methods Gene expression and clinical data for LSCC were obtained from the TCGA and Gene GEO (GSE27020) databases. A risk prediction model associated with VM was established using LASSO and Cox regression analyses. Based on their risk scores, patients with LSCC were categorized into high- and low-risk groups. The disparities in immune infiltration, tumor mutational burden (TMB), and functional enrichment between these two groups were examined. The core genes in LSCC were identified using the machine learning (SVM-RFE) and WGCNA algorithms. Subsequently, the involvement of bone morphogenetic protein 2 (BMP2) in VM and metastasis was investigated both in vitro and in vivo. To elucidate the downstream signaling pathways regulated by BMP2, western blotting was performed. Additionally, Ch
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- Author
- Qingwen Zhu; Xinyu Zhang; Fei Lu; Siyu Miao; Chunyang Zhang; Zhenzhen Liu; Zejun Gao; Meihao Qi; Xiaogang An; Panling Geng; Sufang Wang; Hongbo Ren; Fugen Han; Ruyue Zhang; DingJun Zha
- Publisher
- BioMed Central
- Published
- 2024
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)