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What is T. cruzi Modulates PLC-γ and ERK1/2 in Placenta about?

The study investigates the modulation of Phospholipase C gamma (PLC-c) and ERK1/2 MAPK signaling pathways during the ex vivo infection of human placental chorionic villi by Trypanosoma cruzi. It finds that low concentrations of the parasite activate both pathways, while high concentrations moderately activate PLC-c and inhibit ERK1/2 MAPK. Importantly, inhibiting these pathways does not prevent the infection, indicating their differential roles in the process.

Author

[email protected]

Language

EN