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TDP-43 and NOVA-1 in TNIK Splicing by Mércia Fiuza is a document available to read on EtoBox.
What is TDP-43 and NOVA-1 in TNIK Splicing about?
The study investigates the role of RNA-binding proteins TDP-43 and NOVA-1 in the alternative splicing of the TNIK gene, which is associated with schizophrenia and intellectual disability. It finds that TDP-43 promotes the skipping of TNIK exon 15, while NOVA-1 inhibits this process, suggesting a complex regulatory mechanism in the nervous system. The research highlights the significance of TNIK protein isoforms in regulating neuronal functions and their potential implications in neurodegenerative diseases a
- Author
- Mércia Fiuza
- Language
- EN