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Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway by Junchao Luo; Senbo Zhu; Yu Tong; Yin Zhang; Yong Li; Li Cao; Mingxiang Kong; Min Luo; Qing Bi; Qiong Zhang is a Environmental Science article available to read on EtoBox.
What is Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway about?
## Abstract Osteoplastic precursors are critical for fracture repair and bone homeostasis maintenance. Cerium oxide nanoparticles (CeO~2~ NPs) can promote the osteogenic differentiation of mesenchymal stem cells and secrete vascular endothelial growth factors. However, little is known about its role in precursor osteoblasts; therefore, we further investigated the effect and mechanism of CeO~2~ NPs in precursor osteoblasts. Cell counting kit-8 analysis was utilized to detect the toxicity of CeO~2~ NPs on MC3T3-E1 mouse osteogenic precursor cells. Then, alizarin red S staining was employed to assess the degree of extracellular matrix mineralization, and quantitative real-time polymerase chain reaction analysis was performed to measure the levels of osteogenesis-related genes. To identify differentially expressed genes, mRNA-sequencing was performed. Subsequently, GO and KEGG analyses were deployed to identify the major downstream pathways, whereas Western blot was used for verification. CeO~2~ NPs significantly enhanced the ability of MC3T3-E1 precursor osteoblasts to enhance matrix mineralization and increased the expression of osteogenic genes such as runt-related transcription fac
Who reads Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Junchao Luo; Senbo Zhu; Yu Tong; Yin Zhang; Yong Li; Li Cao; Mingxiang Kong; Min Luo; Qing Bi; Qiong Zhang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Environmental Science (Physical Sciences)