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Intrasubthalamic Injection of 6-Hydroxydopamine Induces Changes in the Firing Rate and Pattern of Subthalamic Nucleus Neurons in the Rat by Zhongge Ni; Rabia Bouali-Benazzouz; Dongming Gao; Alim-Louis Benabid; Abdelhamid Benazzouz is a Neuroscience article available to read on EtoBox.
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## Abstract The subthalamic nucleus (STN) receives dopaminergic projections from the substantia nigra pars compacta (SNc). To investigate the role of direct and indirect dopaminergic influences on STN neurons, the spontaneous activity was studied in four groups of animals: normal rats, rats with intrasubthalamic or intranigral injection of 6‐hydroxydopamine (6‐OHDA), and sham STN injection rats by using extracellular recordings 4 weeks postsurgery. After intrasubthalamic injection of 6‐OHDA, the mean firing rate significantly decreased (7.29 ± 0.39 spikes/sec, __P__ < 0.01 vs. 11.13 ± 0.59 spikes/sec in normal or 11.26 ± 0.57 spikes/sec in sham group), and the percentage of STN neurons discharging regularly decreased significantly (81%, __P__ < 0.05 vs. 90% in normal group or __P__ < 0.01 vs. 92% in sham group) and that of bursty cells increased (19%, __P__ < 0.05 vs. 10%; in normal group or __P__ < 0.01 vs. 8% in sham group). In the group of rats with SNc lesion, the firing rate of subthalamic neurons did not show a significant difference (11.61 ± 0.81 spikes/sec) compared with normal group. However, the firing pattern was dramatically changed: 74% of cells exhibited bursty patter
Who reads Intrasubthalamic Injection of 6-Hydroxydopamine Induces Changes in the Firing Rate and Pattern of Subthalamic Nucleus Neurons in the Rat?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Zhongge Ni; Rabia Bouali-Benazzouz; Dongming Gao; Alim-Louis Benabid; Abdelhamid Benazzouz
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)