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Can I read Phosphorylation of Covalent Organic Framework Nanospheres for Inhibition of Amyloid-β Peptide Fibrillation† on EtoBox?
Phosphorylation of Covalent Organic Framework Nanospheres for Inhibition of Amyloid-β Peptide Fibrillation† by Linli Yao; Zhe Zhou; Suxiao Wang; Qichao Zou; Hang-Xing Wang; Li-Xin Ma; Shengfu Wang; Xiuhua Zhang is a Chemistry article available to read on EtoBox.
What is Phosphorylation of Covalent Organic Framework Nanospheres for Inhibition of Amyloid-β Peptide Fibrillation† about?
The development and exploration of new nanostructural inhibitors against Alzheimer's disease (AD)-associated amyloid-β (Aβ) fibrillation have attracted extensive attention and become a new frontier in nanomedicine. However, focusing on finding an effective nanostructure is one of the most challenging parts of the therapeutics task. Herein, nanoscale spherical covalent organic frameworks (COFs) __via__ post-synthetic functionalization with sodium phosphate (SP) groups on the channel networks were found to efficiently inhibit Aβ fibrillation. The as-prepared uniform SP-COF nanospheres with high surface area, good crystallinity, and chemical stability were characterized by multifarious microscopic and spectroscopic techniques. Moreover, molecular dynamics simulation together with fibrillation kinetics and cytotoxicity assay experiments shows that there were restricted-access adsorption channels in the SP-COFs which were formed by the cavities with size and functional groups accommodated to the Aβ peptide sequence and significantly affected the fibrillation and cytotoxicity of Aβ. Transmission electron microscopy (TEM), dynamic light scattering (DLS) monitoring, isothermal titration ca
Who reads Phosphorylation of Covalent Organic Framework Nanospheres for Inhibition of Amyloid-β Peptide Fibrillation†?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Linli Yao; Zhe Zhou; Suxiao Wang; Qichao Zou; Hang-Xing Wang; Li-Xin Ma; Shengfu Wang; Xiuhua Zhang
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Language
- EN
- Field
- Chemistry (Physical Sciences)