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Prostate-Specific Antigen Level at the Time of Salvage Therapy After Radical Prostatectomy for Prostate Cancer and the Risk of Death by Derya Tilki; Ming-Hui Chen; Jing Wu; Hartwig Huland; Markus Graefen; Osama Mohamad; Janet E. Cowan; Felix Y. Feng; Peter R. Carroll; Anthony V. D'Amico is a Medicine article available to read on EtoBox.

What is Prostate-Specific Antigen Level at the Time of Salvage Therapy After Radical Prostatectomy for Prostate Cancer and the Risk of Death about?

## PURPOSE Both the performance characteristics of prostate-specific membrane antigen positron emission tomography and insurance approval improves with increasing prostate-specific antigen (PSA) level causing some physicians to delay post-radical prostatectomy salvage radiation therapy (sRT) after PSA failure. Yet, it is unknown for men with at most one high-risk factor (ie, pT3/4 or prostatectomy [p] Gleason score 8-10) whether a PSA level exists above which initiating sRT is associated with increased all-cause mortality (ACM)-risk and was investigated. ## METHODS Using a multinational database of 25,551 patients with pT2-4N0 or NXM0 prostate cancer, multivariable Cox regression analysis evaluated whether an association with a significant increase in ACM-risk existed when sRT was delivered above a prespecified PSA level beginning at 0.10 ng/mL and in 0.05 increments up to 0.50 ng/mL versus at or below that level. The model was adjusted for age at and year of radical prostatectomy, established prostate cancer prognostic factors, institution, and the time-dependent use of androgen deprivation therapy. ## RESULTS After a median follow-up of 6.00 years, patients who received sRT at a

Who reads Prostate-Specific Antigen Level at the Time of Salvage Therapy After Radical Prostatectomy for Prostate Cancer and the Risk of Death?

Author

Derya Tilki; Ming-Hui Chen; Jing Wu; Hartwig Huland; Markus Graefen; Osama Mohamad; Janet E. Cowan; Felix Y. Feng; Peter R. Carroll; Anthony V. D'Amico

Publisher

American Society of Clinical Oncology (ASCO)

Published

2023

Language

EN

Field

Medicine (Health Sciences)