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Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by inflammation and fibrosis of bile ducts, often associated with ulcerative colitis. The epidemiology of PSC shows a low incidence of 0.7 to 0.8 cases per 100,000, with higher prevalence in northern Europe and North America, and a notable familial tendency. The pathogenesis remains unclear, but it is believed to involve autoimmune mechanisms, genetic predispositions, and possible microbial influences.
- Author
- Tammy Boud
- Language
- EN