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Prenatal Exposure to a Phthalate Mixture Leads to Multigenerational and Transgenerational Effects on Uterine Morphology and Function in Mice by Li, Kailiang; Liszka, Monika; Zhou, Changqing; Brehm, Emily; Flaws, Jodi A.; Nowak, Romana A. is a Medicine article available to read on EtoBox.
What is Prenatal Exposure to a Phthalate Mixture Leads to Multigenerational and Transgenerational Effects on Uterine Morphology and Function in Mice about?
Phthalates are commonly used plasticizers and additives that are found in plastic containers, children's toys and medical equipment. Phthalates are classified as endocrine-disrupting chemicals and exposure to phthalates has been associated with several human health risks including reproductive defects. Most studies focus on a single phthalate; however, humans are exposed to a mixture of phthalates daily. We hypothesized that prenatal exposure to an environmentally relevant phthalate mixture would lead to changes in uterine morphology and function in mice in a multi-generational manner. To test this hypothesis, pregnant CD-1 dams were orally dosed with vehicle or a phthalate mixture (20 μg/kg/day, 200 μg/kg/day, 200 mg/kg/day, and 500 mg/kg/day) from gestational day 10.5 to parturition. The mixture contained 35 % diethyl phthalate, 21 % di-(2-ethylhexyl) phthalate, 15 % dibutyl phthalate, 15 % diisononyl phthalate, 8% diisobutyl phthalate, and 5% benzylbutyl phthalate. The F1 pups were maintained and mated to produce two more generations (F2 and F3). At the age of 13 months, all females were euthanized and tissue samples were collected in diestrus. Our results showed that exposure t
Who reads Prenatal Exposure to a Phthalate Mixture Leads to Multigenerational and Transgenerational Effects on Uterine Morphology and Function in Mice?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Li, Kailiang; Liszka, Monika; Zhou, Changqing; Brehm, Emily; Flaws, Jodi A.; Nowak, Romana A.
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0890-6238)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)