About this scholarly article

P28 Which factors influence end of life care provision in patients with advanced chronic liver disease: Lessons from the South West by Daniel Maggs; Emma Saunsbury; Benjamin Masterman; Katherine Belfield; Oliver Bendall; Frederica Betteridge; Holly Emms; Sarah Godlee; Sarah Gormley; Dilip Gurung; Prakash Katwal; Laurence Knowles; Holly Lyne; Fenella Marley; Sean Mole; James Nott; Lekshmy Pillai; Keith Pohl; Rhea Randhawa; Giovanna Sheiybani; Ang Dolma Sherpa; Alexander Wallace; Ben Hudson is a scholarly article available to read on EtoBox.

mortality. Linear correlations between NET components and haemostatic parameters demonstrated that cf-gDNA is strongly associated with VWF (r=0.74) and D-dimer (r=0.70), and MPO-DNA also correlates with VWF (r=0.53) and D-dimer (r=0.50) (figure ). Discussion These data reveal that there is excessive coagulation activation as cirrhosis severity worsens. In parallel, cf-gDNA in systemic circulation was notably elevated in ACLF, which we hypothesise is related to increased cell death, and which correlates strongly with coagulation activation and endothelial cell activation. These results may indicate that cf-gDNA and NETs partially compensate for decreases in procoagulant drivers in cirrhosis.

Author

Daniel Maggs; Emma Saunsbury; Benjamin Masterman; Katherine Belfield; Oliver Bendall; Frederica Betteridge; Holly Emms; Sarah Godlee; Sarah Gormley; Dilip Gurung; Prakash Katwal; Laurence Knowles; Holly Lyne; Fenella Marley; Sean Mole; James Nott; Lekshmy Pillai; Keith Pohl; Rhea Randhawa; Giovanna Sheiybani; Ang Dolma Sherpa; Alexander Wallace; Ben Hudson

Published

2022

Language

EN