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Increased frequency of proinflammatory CD4 T cells and pathological levels of serum neurofilament light chain in adult drug‐resistant epilepsy by Oumarou Ouédraogo; Rose‐Marie Rébillard; Hélène Jamann; Victoria Hannah Mamane; Marie‐Laure Clénet; Audrey Daigneault; Boaz Lahav; Timo Uphaus; Falk Steffen; Stefan Bittner; Frauke Zipp; Arline Bérubé; Samuel Lapalme‐Remis; Patrick Cossette; Dang Khoa Nguyen; Nathalie Arbour; Mark R. Keezer; Catherine Larochelle is a Medicine article available to read on EtoBox.

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## Objective: Adult drug-resistant epilepsy (dre) is associated with significant morbidity. infiltration of immune cells is observed in dre epileptic foci; however, the relation between dre and the peripheral immune cell compartment remains only partially understood. we aimed to investigate differences in immune cell populations, cytokines, and neurodegenerative biomarkers in the peripheral blood of subjects with epilepsy versus healthy controls, and in dre compared to well-controlled epilepsy (wce). ## Methods: Peripheral blood mononuclear cells and serum from >120 age- and sex-matched adults suffering from focal onset epilepsy and controls were analyzed by multipanel flow cytometry, multiplex immunoassays, and ultrasensitive single molecule array. ## Results: Using a data-driven analytical approach, we identified that cd4 t cells in the peripheral blood are present in a higher proportion in dre patients. moreover, we observed that the frequency of cd4 t cells expressing proinflammatory cytokines interleukin (il)-17a, il-22, tumor necrosis factor, interferon-γ, and granulocyte-macrophage colony-stimulating factor, but not anti-inflammatory cytokines il-10 and il-4, is elevated in

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Author

Oumarou Ouédraogo; Rose‐Marie Rébillard; Hélène Jamann; Victoria Hannah Mamane; Marie‐Laure Clénet; Audrey Daigneault; Boaz Lahav; Timo Uphaus; Falk Steffen; Stefan Bittner; Frauke Zipp; Arline Bérubé; Samuel Lapalme‐Remis; Patrick Cossette; Dang Khoa Nguyen; Nathalie Arbour; Mark R. Keezer; Catherine Larochelle

Publisher

Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0013-9580)

Published

2020

Language

EN

Field

Medicine (Health Sciences)