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What is Enhanced Antibody Fusion Proteins about?
This study explores the engineering of functional antibody CDR3 fusion proteins, specifically focusing on the bovine antibody BLV1H12, which features an unusually long CDR3H loop. By substituting the knob region of BLV1H12 with bovine granulocyte colony-stimulating factor (bGCSF), the resulting fusion proteins demonstrated enhanced pharmacological properties, including significantly prolonged serum half-lives and sustained neutrophil populations in rodent models. The findings suggest potential for creating
- Author
- Jsjfjdndnxjsi jdjdidkdjx
- Language
- EN