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Does the Risk of Embryo Abnormality Increase in PCOS Women? A Secondary Analysis of a Multicenter, Randomized Controlled Trial by Jiahui Wang; Wei Zhou; Zhiyi Song; Tianxiang Ni; Qian Zhang; Zi-Jiang Chen; Junhao Yan is a Medicine article available to read on EtoBox.
What is Does the Risk of Embryo Abnormality Increase in PCOS Women? A Secondary Analysis of a Multicenter, Randomized Controlled Trial about?
## Abstract ## Context Some studies have reported the early miscarriage rate is higher in polycystic ovary syndrome (PCOS) women. However, there is a lack of evidence as to whether the risk of embryo abnormalities increases in PCOS women. ## Objective This work aimed to evaluate the association between PCOS and embryo ploidy. ## Methods A secondary analysis of a multicenter, randomized controlled trial was conducted from July 2017 to June 2018. The original intent was to identify whether preimplantation genetic test for aneuploidy (PGT-A) improves the live birth rate as compared with in vitro fertilization (IVF). From 14 reproductive centers, 190 patients diagnosed with PCOS and 1:1 age-matched non-PCOS patients were chosen from a PGT-A group. A total of 380 patients with 1118 embryos were included in our study. Intervention included women diagnosed with PCOS, and the main outcome measures were embryonic aneuploidy and embryonic mosaic. ## Results After adjusting for potential confounders, the rate of embryonic aneuploidy and embryonic mosaic in the PCOS group were comparable with the control group (embryonic aneuploid rate PCOS group: 14.0% vs control group: 18.3%, adjusted OR [95
Who reads Does the Risk of Embryo Abnormality Increase in PCOS Women? A Secondary Analysis of a Multicenter, Randomized Controlled Trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jiahui Wang; Wei Zhou; Zhiyi Song; Tianxiang Ni; Qian Zhang; Zi-Jiang Chen; Junhao Yan
- Publisher
- The Endocrine Society
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)