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Klebsiella Pneumoniae: Combating Bio Lm-Associated Infections Using A Bovine Microbial Enzyme by biswajit sarkar is a document available to read on EtoBox.
The study presents a bovine microbial enzyme, GH-B2, which effectively prevents and degrades biofilms of multidrug-resistant Klebsiella pneumoniae, a major clinical challenge. GH-B2 demonstrated a low IC50 of 2.50 μM for preventing biofilm formation and an EC50 of 1.94 μM for degrading established biofilms, enhancing the efficacy of antibiotics like meropenem. This enzyme shows promise for in vivo applications due to its stability and lack of toxicity to mammalian and microbial cells.
- Author
- biswajit sarkar
- Language
- EN