Opening book details…
Can I read Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Southern Brazil on EtoBox?
Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Southern Brazil by Ludmila Gonçalves Entiauspe; Fabiana Kömmling Seixas; Emily Montosa Nunes; Fernanda Martins Rodrigues; Odir A. Dellagostin; Tiago Collares; Mariângela Freitas da Silveira is a Medicine article available to read on EtoBox.
What is Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Southern Brazil about?
## Background It is believed that Human Papillomavirus (HPV) and Human Immunodeficiency Virus coinfection contributes to increase the risk for cervical intraepithelial injuries. Several factors may contribute to cervical cancer (CC) development, including genetic variants such as __TP53__ and __MDM2__ gene polymorphisms. ## Materials and methods A hundred HIV-infected women were examined for HPV detection and its genotypes, as well as the frequencies of the SNPs Arg72Pro and SNP309 and their associations with CC risk factors. Nested Polymerase Chain Reaction (nPCR) was used for HPV detection and PCR-RFLP for __TP53__ and MDM2 SNP309 genotyping. ## Results HPV DNA was detected in 68% of samples. A higher frequency of low-risk HPV genotypes (66.7%) was observed when compared to high-risk genotypes (33.3%). Nine different HPV genotypes were identified, with the highest prevalence of HPV-6, followed by HPV-16 and 31. p53 Arg72Arg and SNP309 TG genotype were the most prevalent. HPV genotyping was performed by sequencing. ## Conclusion The data obtained suggest that HIV-infected women are more susceptible to be infected by low-risk HPV (LR-HPV) genotypes than by high-risk (HR-HPV), and P
Who reads Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Southern Brazil?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ludmila Gonçalves Entiauspe; Fabiana Kömmling Seixas; Emily Montosa Nunes; Fernanda Martins Rodrigues; Odir A. Dellagostin; Tiago Collares; Mariângela Freitas da Silveira
- Publisher
- Elsevier BV
- Published
- 2014
- Language
- EN
- Field
- Medicine (Health Sciences)