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Enhanced thromboprophylaxis in critically ill patients with COVID-19 infection by Kummer, R.L. (author);Considine, K.A. (author);Rankin, M.A. (author);Hubbard, L.M. (author);Lam, T.S. (author);Thornton, L.T. (author);Lindsay, A.R. (author);Ahiskali, A.S. (author);Leatherman, J.W. (author) is a Medicine article available to read on EtoBox.

What is Enhanced thromboprophylaxis in critically ill patients with COVID-19 infection about?

Background: Patients with severe SARS-CoV-2 infection have been shown to have abnormal coagulation parameters and are at increased risk of thromboembolism. The optimal thromboprophylaxis regimen that minimizes thrombosis without increased risk of serious bleeding is uncertain. Objectives: To describe the efficacy and safety of increased intensity (enhanced) thromboprophylaxis in patients with COVID-19 admitted to the medical intensive care unit (MICU). Methods: This is a retrospective cohort analysis of patients with a diagnosis of COVID-19 admitted to the MICU of an urban safety net hospital. With the exception of patients being supported with extracorporeal membrane oxygenation or on chronic anticoagulation who received therapeutic dosing of anticoagulation, thromboprophylaxis was given as either enoxaparin or unfractionated heparin in doses higher than those recommended for standard prophylaxis, but lower than those used for therapeutic anticoagulation. Main results: Of the 120 patients managed with an enhanced thromboprophylaxis protocol, 6 (5%) experienced thromboembolism as a result of their COVID-19 disease (1 pulmonary embolus, 4 deep vein thromboses, and 1 arterial embolis

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Author

Kummer, R.L. (author);Considine, K.A. (author);Rankin, M.A. (author);Hubbard, L.M. (author);Lam, T.S. (author);Thornton, L.T. (author);Lindsay, A.R. (author);Ahiskali, A.S. (author);Leatherman, J.W. (author)

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)