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The in vitro PDT efficacy of a novel metallophthalocyanine (MPc) derivative and established 5‐ALA photosensitizing dyes against human metastatic melanoma cells by C.A. Robertson; H. Abrahamse is a Medicine article available to read on EtoBox.

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## Abstract ## Background and Objective Numerous worldwide clinical trials have shown that photodynamic therapy (PDT) represents an effective and safe modality for various skin disorders, but little research has been done in terms of its effect on malignant melanomas (MM). Thus, the aim of this study was to compare the effect of both established porphyrin photosensitizer 5‐aminolevulinic acid (5‐ALA) and novel metallophthalocyanine (MPc) photosensitizer on human metastatic skin cells which produce a MM. ## Materials and Methods The cellular responses following PDT were assessed using changes in cell morphology, cell viability, cytotoxicity, apoptosis, and proliferation. ## Results Findings reported that in vitro human MM cell line A375 (EACC no: 88113005) are highly sensitive to growth inhibition and apoptosis induction by the cytotoxic side‐effects induced by MPc and 5‐ALA photosensitizing treatments post‐laser irradiation at 680 and 636 nm, respectively. The decrease of cell viability accompanied by an increased cytotoxicity and apoptotic and necrotic levels, with a time‐dependant decrease in cellular proliferation was found to be far more significant for MPc‐treated cells than 5

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Author

C.A. Robertson; H. Abrahamse

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)

Published

2010

Language

EN

Field

Medicine (Health Sciences)