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Can I read FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance on EtoBox?
FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance by Thomas Rasmussen; Heidi Rye Hudlebusch; Lene Meldgaard Knudsen; Hans Erik Johnsen is a Medicine article available to read on EtoBox.
What is FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance about?
**Summary.** The t(4:14) translocation affects two potential oncogenes, FGFR3 and MMSET, in multiple myeloma (MM). We investigated the frequency of FGFR3 dysregulation and its prognostic value in MM. FGFR3 mRNA levels were determined in 110 diagnostic bone marrow (BM) samples from MM patients. In addition, selected BM samples were screened for elevated MMSET mRNA levels. 14·5% (16/110) of MM BM samples showed dysregulated FGFR3 expression. Follow‐up of 76 MM patients showed no significant difference between FGFR3 dysfunction and survival (__P__ = 0·3) or correlation with known prognostic factors. Further, no linear relation was observed between FGFR3 and MMSET levels.
Who reads FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Thomas Rasmussen; Heidi Rye Hudlebusch; Lene Meldgaard Knudsen; Hans Erik Johnsen
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)