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Ductular Reaction-associated Neutrophils Promote Biliary Epithelium Proliferation in Chronic Liver Disease by Silvia Ariño; Beatriz Aguilar-Bravo; Mar Coll; Woo-Yong Lee; Moritz Peiseler; Paula Cantallops-Vilà; Laura Sererols-Viñas; Raquel A. Martínez-García de la Torre; Celia Martínez-Sánchez; Jordi Pedragosa; Laura Zanatto; Jordi Gratacós-Ginès; Elisa Pose; Delia Blaya; Xènia Almodóvar; María Fernández-Fernández; Paloma Ruiz-Blázquez; Juan José Lozano; Silvia Affo; Anna M. Planas; Pere Ginès; Anna Moles; Paul Kubes; Pau Sancho-Bru is a Medicine article available to read on EtoBox.

What is Ductular Reaction-associated Neutrophils Promote Biliary Epithelium Proliferation in Chronic Liver Disease about?

Background & aims Ductular reaction expansion is associated with poor prognosis in patients with advanced liver disease. However, the mechanisms promoting biliary cell proliferation are largely unknown. Here we identify neutrophils as drivers of biliary cell proliferation and defective wound-healing response. Methods Liver tissue location of neutrophil was evaluated in patients with chronic liver disease. Neutrophil dynamics was analyzed by intravital microscopy and neutrophil-labeling assays in DDC treated mice. Neutrophil depletion or recruitment inhibition was achieved using Ly6g antibody and CXCR1/2 inhibitor, respectively. Mice deficient in PAD4 and neutrophil elastase (NE) were used to investigate the mechanisms underlying ductular reaction expansion. Results In this study we describe a population of ductular reaction-associated neutrophils (DRANs), which are in direct contact to the biliary epithelial cells in chronic liver diseases and their number increases along disease progression. We show that DRANs are immobilized at the ductular reaction for a prolonged period of time. In addition, liver neutrophils display a unique phenotypic and transcriptomic profile, showing a dec

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Author

Silvia Ariño; Beatriz Aguilar-Bravo; Mar Coll; Woo-Yong Lee; Moritz Peiseler; Paula Cantallops-Vilà; Laura Sererols-Viñas; Raquel A. Martínez-García de la Torre; Celia Martínez-Sánchez; Jordi Pedragosa; Laura Zanatto; Jordi Gratacós-Ginès; Elisa Pose; Delia Blaya; Xènia Almodóvar; María Fernández-Fernández; Paloma Ruiz-Blázquez; Juan José Lozano; Silvia Affo; Anna M. Planas; Pere Ginès; Anna Moles; Paul Kubes; Pau Sancho-Bru

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)