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What is Clausenamide Mitigates Liver Ferroptosis about?

(+)-Clausenamide ((+)-CLA) has been identified as a protective agent against drug-induced liver injury, specifically by inhibiting ferroptosis in hepatocytes caused by acetaminophen. The study demonstrates that (+)-CLA interacts with the Keap1 protein, enhancing Nrf2 stability and activating the Keap1–Nrf2 pathway, which helps mitigate liver damage. This research provides insights into the mechanisms of acetaminophen-induced liver injury and suggests a novel therapeutic approach using (+)-CLA.

Author

Nguyễn Kim Anh

Language

EN