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Loss of neurofibromatosis type I (NFI) gene expression in pheochromocytomas from patients without NFI by David H. Gutmann; Robert T. Geist; Kamala Rose; Goran Wallin; Jeffrey F. Moley is a Medicine article available to read on EtoBox.

What is Loss of neurofibromatosis type I (NFI) gene expression in pheochromocytomas from patients without NFI about?

## Abstract The neurofibromatosis type 1 (__NFI__) gene encodes a tumor‐suppressor protein termed neurofibromin, which, in adults, is expressed predominantly in neurons, Schwann cells, and the adrenal medulla. Loss of __NFI__ gene expression has been reported in Schwann cell tumors (neurofibrosarcomas) from patients with NF1 as well as in malignant melanomas and neuroblastomas from patients without NF1. Previously, we demonstrated the lack of neurofibromin expression in six pheochromocytomas from patients with NF1, supporting the idea that neurofibromin might be an essential regulator of cell growth in these cells. To determine whether __NFI__ gene expression is similarly altered in pheochromocytomas from patients without NF1, we examined 20 pheochromocytomas for the presence of __NFI__ RNA and neurofibromin by reverse‐transcribed polymerase chain reaction (RT‐PCR) and immunohistochemistry, respectively. Reduced or absent __NFI__ gene expression was documented in 7 of these 20 tumors (35%) including 1 of 4 sporadic tumors, 3 of 10 tumors from patients with multiple endocrine neoplasia (MEN) 2A, 2 of 4 tumors from patients with MEN2B, and 1 of 2 tumors from patients with von Hippel‐

Who reads Loss of neurofibromatosis type I (NFI) gene expression in pheochromocytomas from patients without NFI?

Author

David H. Gutmann; Robert T. Geist; Kamala Rose; Goran Wallin; Jeffrey F. Moley

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

1995

Language

EN

Field

Medicine (Life Sciences)