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Computed tomography findings as determinants of pulmonary function tests in fibrotic interstitial lung diseases—Network-analyses and multivariate models by David Lang; Kaveh Akbari; Stefan Walcherberger; Benedikt Hergan; Andreas Horner; Magdalena Hepp; Bernhard Kaiser; Herwig Pieringer; Bernd Lamprecht is a Medicine article available to read on EtoBox.
What is Computed tomography findings as determinants of pulmonary function tests in fibrotic interstitial lung diseases—Network-analyses and multivariate models about?
The aim was to evaluate the impact of multiple high-resolution computed tomography (HRCT) features on pulmonary function test (PFT) biomarkers in fibrotic interstitial lung disease (FILD) patients. HRCT of subsequently ILD-board-discussed FILD patients were semi-quantitatively evaluated in a standardized approach: 18 distinct lung regions were scored for noduli, reticulation, honeycombing, consolidations, ground glass opacities (GGO), traction bronchiectasis (BRK) and emphysema. Total lung capacity (TLC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC, diffusion capacity for carbon monoxide (DLCO) and transfer coefficient (KCO) were assessed. Interactions between each PFT biomarker and all HRCT scores were visualized by network analyses, modeled according to the Schwarz Bayesian Information Criterion and incorporated in uni- and multivariate stepwise regression analyses. Among 108 FILD patients (mean age 67 years, 77% male), BRK extent was a major significant uni- or multivariate determinant of all PFT analyzed. Besides that, diffusion-based variables DLCO and KCO showed a larger dependency on reticulation, emphysema and GGO, while forced expirat
Who reads Computed tomography findings as determinants of pulmonary function tests in fibrotic interstitial lung diseases—Network-analyses and multivariate models?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- David Lang; Kaveh Akbari; Stefan Walcherberger; Benedikt Hergan; Andreas Horner; Magdalena Hepp; Bernhard Kaiser; Herwig Pieringer; Bernd Lamprecht
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)