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NAT2 slow acetylation and bladder cancer in workers exposed to benzidine by Tania Carreón; Avima M. Ruder; Paul A. Schulte; Richard B. Hayes; Nathaniel Rothman; Martha Waters; Delores J. Grant; Robert Boissy; Douglas A. Bell; Fred F. Kadlubar; George P. Hemstreet III; Songnian Yin; Grace K. LeMasters is a Medicine article available to read on EtoBox.

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## Abstract This study expands a previous study of __NAT2__ polymorphisms and bladder cancer in male subjects occupationally exposed only to benzidine. The combined analysis of 68 cases and 107 controls from a cohort of production workers in China exposed to benzidine included 30 new cases and 67 controls not previously studied. NAT2 enzymatic activity phenotype was characterized by measuring urinary caffeine metabolite ratios. PCR‐based methods identified genotypes for __NAT2__, __NAT1__ and __GSTM1__. NAT2 phenotype and genotype data were consistent. A protective association was observed for the slow __NAT2__ genotype (bladder cancer OR = 0.3; 95% CI = 0.1 = 1.0) after adjustment for cumulative benzidine exposure and lifetime smoking. Individuals carrying __NAT1wt/\*10__ and __NAT1\*10/\*10__ showed higher relative risks of bladder cancer (OR = 2.8, 95% CI = 0.8–10.1 and OR = 2.2, 95% CI = 0.6–8.3, respectively). No association was found between __GSTM1__ null and bladder cancer. A metaanalysis risk estimate of case‐control studies of NAT2 acetylation and bladder cancer in Asian populations without occupational arylamine exposures showed an increased risk for slow acetylators. Th

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Author

Tania Carreón; Avima M. Ruder; Paul A. Schulte; Richard B. Hayes; Nathaniel Rothman; Martha Waters; Delores J. Grant; Robert Boissy; Douglas A. Bell; Fred F. Kadlubar; George P. Hemstreet III; Songnian Yin; Grace K. LeMasters

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2005

Language

EN

Field

Medicine (Health Sciences)