Can I read Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development on EtoBox?

Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development by C. Y. Kawanishi; P. Hartig; K. L. Bobseine; J. Schmid; M. Cardon; G. Massenburg; N. Chernoff is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development about?

## Abstract Retinoic acid (RA) alters the developmental fate of the axial skeletal anlagen. “Anteriorizations” or “posteriorizations,” the assumption of characteristics of embryonic areas normally anterior or posterior to the affected tissues, are correlated with altered embryonal expression domains of Hox genes after in utero RA treatment. These “homeotic” changes have been hypothesized to result from alterations of a “Hox cod” which imparts positional identity in the axial skeleton. To investigate whether such developmental alterations were specific to RA, or were a more general response to xenobiotic exposure, CD‐1 pregnant mice were exposed to RA, valproic acid (VA), or bromoxynil (Br) during organogenesis. Additionally, the expression domains of two Hox genes, Hoxa7 and Hoxa10, were examined in gestation day (GD) 12.5 embryos obtained from control, RA, VA, or Br, treated gravid dams exposed on GD 6, 7, or 8. The anterior expression boundary of Hoxa7 is at the level of the C7/T1 vertebrae and that of Hoxa10 is at L6/S1. Compound‐induced changes in the incidence of skeletal variants were observed. These included supernumerary cervical ribs (CSNR) lateral to C7, 8 vertebrosternal

Who reads Axial Skeletal and Hox Expression Domain Alterations Induced by Retinoic Acid, Valproic Acid, and Bromoxynil During Murine Development?

Author

C. Y. Kawanishi; P. Hartig; K. L. Bobseine; J. Schmid; M. Cardon; G. Massenburg; N. Chernoff

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1095-6670)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)