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Synthesis of a Conformationally Restricted Analogue of Paclitaxel by Luciano Barboni; Catia Lambertucci; Roberto Ballini; Giovanni Appendino; Ezio Bombardelli is a scholarly article available to read on EtoBox.

What is Synthesis of a Conformationally Restricted Analogue of Paclitaxel about?

A conformationally constrained analogue of the paclitaxel side-chain was synthesised in an enantioselective way from ethyl IH-indene-2-carboxylate. Coupling with 7-triethylsilylbaccatin III and deprotection afforded 2',2"-methylenepaclitaxel, a novel analogue of the natural product retaining anticancer activity.

Author

Luciano Barboni; Catia Lambertucci; Roberto Ballini; Giovanni Appendino; Ezio Bombardelli

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

1998

Language

EN