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This research paper discusses the synthesis and evaluation of thiazole orange (TO) derivatives as potent inhibitors of human telomerase, particularly highlighting the TO-spermine conjugate which exhibits inhibition comparable to BRACO-19. The study demonstrates that the incorporation of amino side chains enhances the binding affinity of these derivatives to G-quadruplex DNA, while maintaining selectivity over duplex DNA. The findings suggest that TO derivatives can serve as a scaffold for developing novel G

Author

9616ratnesh

Language

EN