Can I read Planarians as a Model to Study Neurotoxic Agents on EtoBox?

Planarians as a Model to Study Neurotoxic Agents by Danielle Ireland; Eva-Maria S. Collins is a book available to read on EtoBox.

What is Planarians as a Model to Study Neurotoxic Agents about?

The developing brain is more vulnerable to chemicals than the adult brain, but environmental chemicals have only been sparingly tested for developmental neurotoxicity (DNT). This data sparsity arises from the extreme cost and duration of mammalian toxicity testing required for regulatory decision making. To close this knowledge gap, alternative non-animal test methods are being developed for rapid and cost-effective screening. While all models have limitations, integrated testing strategies that incorporate data from multiple test methods, spanning computational, in vitro, and in vivo approaches, promise to better predict human toxicity. In vivo models using invertebrates allow for rapid systems-level toxicity testing to complement human cell culture models that lack this capacity. Behavior is used as a functional readout of nervous system operation, while morphological and biochemical assays can assess damage to physiological and cellular processes. Freshwater planarians have emerged as a new invertebrate model for systems-level neurotoxicity and DNT testing. Planarians regenerate their brain following head amputation or asexual reproduction. For asexual planarians, neuroregenerat

Author

Danielle Ireland; Eva-Maria S. Collins

Publisher

Elsevier Science & Technology

Published

2023

Language

EN

ISBN

9780443185823

Subjects

Science, Chemistry, Medicine