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Inhibition of Flippase-like Activity by Tubulin Regulates Phosphatidylserine Exposure in Erythrocytes from Hypertensive and Diabetic Patients by Tamara Muhlberger; Melisa Micaela Balach; Carlos Gastón Bisig; Verónica Silvina Santander; Noelia Edith Monesterolo; Cesar Horacio Casale; Alexis Nazareno Campetelli is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Inhibition of Flippase-like Activity by Tubulin Regulates Phosphatidylserine Exposure in Erythrocytes from Hypertensive and Diabetic Patients about?
## Abstract Plasma membrane tubulin is an endogenous regulator of P-ATPases and the unusual accumulation of tubulin in the erythrocyte membrane results in a partial inhibition of some their activities, causing hemorheological disorders like reduced cell deformability and osmotic resistance. These disorders are of particular interest in hypertension and diabetes, where the abnormal increase in membrane tubulin may be related to the disease development. Phosphatidylserine (PS) is more exposed on the membrane of diabetic erythrocytes than in healthy cells. In most cells, PS is transported from the exoplasmic to the cytoplasmic leaflet of the membrane by lipid flippases. Here, we report that PS is more exposed in erythrocytes from both hypertensive and diabetic patients than in healthy erythrocytes, which could be attributed to the inhibition of flippase activity by tubulin. This is supported by: (i) the translocation rate of a fluorescent PS analog in hypertensive and diabetic erythrocytes was slower than in healthy cells, (ii) the pharmacological variation of membrane tubulin in erythrocytes and K562 cells was linked to changes in PS translocation and (iii) the P-ATPase-dependent PS
Who reads Inhibition of Flippase-like Activity by Tubulin Regulates Phosphatidylserine Exposure in Erythrocytes from Hypertensive and Diabetic Patients?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tamara Muhlberger; Melisa Micaela Balach; Carlos Gastón Bisig; Verónica Silvina Santander; Noelia Edith Monesterolo; Cesar Horacio Casale; Alexis Nazareno Campetelli
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)