About this document
Bioisosterism in Drug Discovery by Umy Mardhiyah is a document available to read on EtoBox.
This document discusses bioisosterism, a molecular modification strategy used in drug discovery. It involves replacing molecular fragments with other fragments that have similar physicochemical properties. The concept of bioisosterism was introduced in 1951 to describe how isosteric replacements can impact biological activity. There are two categories of bioisosterism: classic, involving atoms/groups with the same valence electrons, and non-classic, which includes more challenging replacements like retroiso
- Author
- Umy Mardhiyah
- Language
- EN