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Patients with Psoriasis Have a Dysbiotic Taxonomic and Functional Gut Microbiota* by Tanja Todberg; Alexander Egeberg; Claus Zachariae; Nikolaj Sørensen; Oluf Pedersen; Lone Skov is a Medicine article available to read on EtoBox.

What is Patients with Psoriasis Have a Dysbiotic Taxonomic and Functional Gut Microbiota* about?

## Background: Accumulating evidence supports the findings of an altered gut microbiota in patients with autoimmune disease. however, existing studies on the role of the gut microbiota in patients with psoriasis have demonstrated conflicting results and have mainly been based on 16s rrna gene sequencing analysis. ## Objectives: To examine whether the gut microbiota of patients with psoriasis was altered in composition and functional potentials compared with healthy controls, and as a second approach compared with healthy cohabitant partners. a further aim was to investigate relationships to disease severity, and seasonal impact on the gut microbiota. ## Methods: In a case-control study, 126 faecal samples were collected from a sample of 53 systemically untreated patients with plaque psoriasis; 52 healthy controls matched for age, sex and body mass index; and 21 cohabitant partners. a subpopulation of 18 patients with psoriasis and 19 healthy controls continued in a longitudinal study, where four to six faecal samples were collected over 9-12 months. the gut microbiota was characterized using shotgun metagenomic sequencing analysis. ## Results: A significantly lower richness (p = 0·

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Author

Tanja Todberg; Alexander Egeberg; Claus Zachariae; Nikolaj Sørensen; Oluf Pedersen; Lone Skov

Publisher

Oxford University Press (OUP)

Published

2022

Language

EN

Field

Medicine (Health Sciences)