Can I read EBV Infection and Multiple Sclerosis: Lessons from a Marmoset Model on EtoBox?
EBV Infection and Multiple Sclerosis: Lessons from a Marmoset Model by Bert A. ‘tHart; Yolanda S. Kap; Elena Morandi; Jon D. Laman; Bruno Gran is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is EBV Infection and Multiple Sclerosis: Lessons from a Marmoset Model about?
Multiple sclerosis (MS) is thought to be initiated by the interaction of genetic and environmental factors, eliciting an autoimmune attack on the central nervous system. Epstein-Barr virus (EBV) is the strongest infectious risk factor, but an explanation for the paradox between high infection prevalence and low MS incidence remains elusive. We discuss new data using marmosets with experimental autoimmune encephalomyelitis (EAE) - a valid primate model of MS. The findings may help to explain how a common infection can contribute to the pathogenesis of MS. We propose that EBV infection induces citrullination of peptides in conjunction with autophagy during antigen processing, endowing B cells with the capacity to cross-present autoantigen to CD8CD56 T cells, thereby leading to MS progression.
Who reads EBV Infection and Multiple Sclerosis: Lessons from a Marmoset Model?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Bert A. ‘tHart; Yolanda S. Kap; Elena Morandi; Jon D. Laman; Bruno Gran
- Publisher
- Elsevier BV
- Published
- 2016
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)