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Retrospective analysis of the clinical features of 172 patients with BCR-ABL1 -negative chronic myeloproliferative neoplasms by Lin, Xiaolan; Huang, Huifang; Chen, Ping is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background To explore the clinical features of the patients with __BCR-ABL1__-negative chronic myeloproliferative neoplasms (MPNs) in our hospital and to reveal the unique features of __BCR-ABL1__-negative MPNs patients in our center. ## Methods Retrospective analysis of routine karyotype analysis results, driver gene mutations and other related clinical parameters of 172 patients with newly diagnosed __BCR-ABL1__-negative MPNs who were admitted to our hospital between October 2013 and June 2018. ## Results (1) The rate of karyotypic abnormalities were 25, 6.3 and 2.9% in primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET) patients, respectively. (2) The mutation rate of __JAK2-V617F__ was 62.5%, and that of the __CALR__, __MPL__ and __EZH2__ genes was 4.2% in PMF. The mutation rates of __JAK2-V617F__ and __JAK2-12__exon were 91.3 and 1.3% in PV, respectively. The mutation rates of __JAK2-V617F__ and CALR were 69.1 and 11.8% in ET, respectively. (3) Patients with __JAK2-V617F mutation__ than with the wild-type gene were more often female in PMF (__P__ = 0.027); had higher peripheral blood white blood cell (WBC) counts (__P__ = 0.006), platelet

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Author

Lin, Xiaolan; Huang, Huifang; Chen, Ping

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2008-; Springer Science and Business Media LLC (ISSN 1755-8166)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)