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A study evaluated the effects of a daily 5 mg folic acid supplement over 90 days in 30 healthy Brazilian adults, finding a significant increase in serum unmetabolized folic acid and a reduction in natural killer (NK) cell cytotoxicity. Serum folate concentrations increased approximately fivefold, while the number and cytotoxicity of NK cells decreased significantly. The study suggests that high-dose folic acid supplementation may alter immune responses, warranting further investigation into its long-term ef

Author
rocioramundi
Language
EN