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Trans-anethole, the Major Constituent of the Essential Oil of Anise, Improves the Antiarthritic Effects of Methotrexate in Rats by Carla Indianara Bonetti; Jackeline Joyce da Silva Moreira; Edvalkia Magna Teobaldo da Rocha; Evelyn Silva Moreira; Jurandir Fernando Comar; Anacharis Babeto de Sá-Nakanishi; Adelar Bracht; Ciomar Aparecida Bersani-Amado; Lívia Bracht is a scholarly article available to read on EtoBox.

What is Trans-anethole, the Major Constituent of the Essential Oil of Anise, Improves the Antiarthritic Effects of Methotrexate in Rats about?

The aim of this study was to evaluate the effect of trans-anethole in combination with methotrexate, compared to monotherapy with trans-anethole or methotrexate, on inflammatory parameters and oxidative stress of arthritic rats. The experimental model of arthritis induced by Freund's complete adjuvant (AIA) in rats was used. Treatment with trans-anethole and methotrexate, in combination or monotherapy, was started on the day of AIA induction and continued for 21 days. The association of anethole (62.5 mg/Kg) to methotrexate (6 mg/Kg) therapy was able to further reduce both the oxidative stress induced by arthritis and the inflammatory events that characterize the disease, as demonstrated by the following indicators: 1) decrease in the edema of the hind legs, in the score of secondary lesions, in the recruitment of leukocytes to the articular cavity and in the plasma myeloperoxidase activity; 2) increase in plasma content of reduced thiols and total antioxidant capacity; 3) diminution of protein carbonylation in plasma, liver and kidneys; 4) decrease in lipid peroxidation in the liver; 5) reduction in the hepatic ROS content; 6) enhancement of the activity of the antioxidant enzymes

Author

Carla Indianara Bonetti; Jackeline Joyce da Silva Moreira; Edvalkia Magna Teobaldo da Rocha; Evelyn Silva Moreira; Jurandir Fernando Comar; Anacharis Babeto de Sá-Nakanishi; Adelar Bracht; Ciomar Aparecida Bersani-Amado; Lívia Bracht

Publisher

Research, Society and Development

Published

2022

Language

EN