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Significance and therapeutic potential of prostaglandin E2 receptor in hepatic ischemia/reperfusion injury in mice by Yukiyasu Kuzumoto; Masayuki Sho; Naoya Ikeda; Kaoru Hamada; Takashi Mizuno; Satoru Akashi; Yoshikazu Tsurui; Hisanori Kashizuka; Takeo Nomi; Atsushi Kubo; Hiromichi Kanehiro; Yoshiyuki Nakajima is a Medicine article available to read on EtoBox.
What is Significance and therapeutic potential of prostaglandin E2 receptor in hepatic ischemia/reperfusion injury in mice about?
Prostaglandin E 2 (PGE 2 ) mediates a variety of innate and adaptive immunity through four distinct receptors: EP1-EP4. It has been suggested that each EP plays a unique and pivotal role in various disease conditions. We investigated the pathophysiological role of EP receptors in hepatic ischemia/reperfusion (I/R) injury. In this study, a 70% hepatic ischemic model was used in male C57BL/6 mice. Selective EP agonists were used to clarify the function of each PGE 2 receptor in I/R injury. Although all four receptors were expressed in the naı ̈ve liver, EP4 expression was significantly upregulated after hepatic I/R. Although EP1, 2, or 3 agonists did not show any protective effect on liver function, the EP4 agonist significantly inhibited hepatic I/R injury as determined by serological and histological analyses. Furthermore, the EP4 agonist downregulated the local expressions of several proinflammatory cytokines, chemokines, and adhesion molecules in the early phase of reperfusion. In contrast, it augmented the local expression of an anti-inflammatory cytokine, interleukin 10. Additionally, the neutrophil accumulation was also inhibited by EP4 agonist treatment. Finally, to confirm
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- Author
- Yukiyasu Kuzumoto; Masayuki Sho; Naoya Ikeda; Kaoru Hamada; Takashi Mizuno; Satoru Akashi; Yoshikazu Tsurui; Hisanori Kashizuka; Takeo Nomi; Atsushi Kubo; Hiromichi Kanehiro; Yoshiyuki Nakajima
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)