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Can I read Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents on EtoBox?
Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents by Tesfaye Biftu; Dennis Feng; Michael Fisher; Gui-Bai Liang; Xiaoxia Qian; Andrew Scribner; Richard Dennis; Shuliang Lee; Paul A. Liberator; Chris Brown; Anne Gurnett; Penny S. Leavitt; Donald Thompson; John Mathew; Andrew Misura; Samantha Samaras; Tamas Tamas; Joseph F. Sina; Kathleen A. McNulty; Crystal G. McKnight; Dennis M. Schmatz; Matthew Wyvratt is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents about?
Compounds 10a (IC 50 110 pM) and 21 (IC 50 40 pM) are the most potent inhibitors of Eimeria tenella cGMP-dependent protein kinase activity reported to date and are efficacious in the in vivo antiparasitic assay when administered to chickens at 12.5 and 6.25 ppm levels in the feed. However, both compounds are positive in the Ames microbial mutagenesis assay which precludes them from further development as antiprotozoal agents in the absence of negative lifetime rodent carcinogenicity studies.
Who reads Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tesfaye Biftu; Dennis Feng; Michael Fisher; Gui-Bai Liang; Xiaoxia Qian; Andrew Scribner; Richard Dennis; Shuliang Lee; Paul A. Liberator; Chris Brown; Anne Gurnett; Penny S. Leavitt; Donald Thompson; John Mathew; Andrew Misura; Samantha Samaras; Tamas Tamas; Joseph F. Sina; Kathleen A. McNulty; Crystal G. McKnight; Dennis M. Schmatz; Matthew Wyvratt
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)