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CircRNA WHSC1 targets the miR‐646/NPM1 pathway to promote the development of endometrial cancer by Liu, Yao; Chen, Shuo; Zong, ZhiâHong; Guan, Xue; Zhao, Yang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is CircRNA WHSC1 targets the miR‐646/NPM1 pathway to promote the development of endometrial cancer about?

## Abstract Circular RNAs (circRNAs) play important roles in human cancer progression. Their high stability and tissue specificity make circRNAs important molecular targets for clinical diagnosis, treatment and prognosis. However, the functions and molecular mechanisms of circRNA WHSC1 in endometrial cancer are unknown. CircWHSC1 expression in normal endometrial and endometrial cancer tissues was detected using PCR. Overexpression or knockdown of circWHSC1 in endometrial cancer cell lines HEC‐1B or Ishikawa, respectively, cell function experiments were used to detect the impact of circWHSC1 on endometrial cancer cells. A nude mouse xenograft model was used to detect changes in tumorigenesis of HEC‐1B cells after circWHSC1 overexpression. Bioinformatics and dual luciferase reporter gene technology were used to predict and validate the sponging ability of circWHSC1 on microRNAs. Gene expression changes were detected by using Western blotting. CircWHSC1 expression was increased in endometrial cancer tissues. CircWHSC1 overexpression promoted the proliferation, migration and invasion of endometrial cancer cells and decreased apoptosis. CircWHSC1 knockdown had the opposite effect. CircW

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Author

Liu, Yao; Chen, Shuo; Zong, ZhiâHong; Guan, Xue; Zhao, Yang

Publisher

Carol Davila University of Medicine Bucharest, Romania; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 1582-1838)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)