Can I read Quinoline- and Isoindoline-Integrated Polycyclic Compounds as Antioxidant, and Antidiabetic Agents Targeting the Dual Inhibition of α-Glycosidase and α-Amylase Enzymes on EtoBox?

Quinoline- and Isoindoline-Integrated Polycyclic Compounds as Antioxidant, and Antidiabetic Agents Targeting the Dual Inhibition of α-Glycosidase and α-Amylase Enzymes by Mohammed Al-Ghorbani; Osama Alharbi; Abdel-Basit Al-Odayni; Naaser A. Y. Abduh is a Medicine article available to read on EtoBox.

What is Quinoline- and Isoindoline-Integrated Polycyclic Compounds as Antioxidant, and Antidiabetic Agents Targeting the Dual Inhibition of α-Glycosidase and α-Amylase Enzymes about?

Novel analogs of quinoline and isoindoline containing various heterocycles, such as tetrazole, triazole, pyrazole, and pyridine, were synthesized and characterized using FT-IR, NMR, and mass spectroscopy, and their antioxidant and antidiabetic activities were investigated. The previously synthesized compound **1** was utilized in conjugation with ketone-bearing tetrazole and isoindoline-1,3-dione to synthesize Schiff’s bases **2** and **3**. Furthermore, hydrazide **1** was treated with aryledines to provide pyrazoles **4a**–**c**. Compound **5** was obtained by treating **1** with potassium thiocyanate, which was then cyclized in a basic solution to afford triazole **6**. On the other hand, pyridine derivatives **7a**–**d** and **8a**–**d** were synthesized using 2-(4-acetylphenyl)isoindoline-1,3-dione via a one-pot condensation reaction with aryl aldehydes and active methylene compounds. From the antioxidant and antidiabetic studies, compound **7d** showed significant antioxidant activity with an EC~50~ = 0.65, 0.52, and 0.93 mM in the free radical scavenging assays (DPPH, ABTS, and superoxide anion radicals). It also displayed noteworthy inhibitory activity against both enzymes

Who reads Quinoline- and Isoindoline-Integrated Polycyclic Compounds as Antioxidant, and Antidiabetic Agents Targeting the Dual Inhibition of α-Glycosidase and α-Amylase Enzymes?

Author

Mohammed Al-Ghorbani; Osama Alharbi; Abdel-Basit Al-Odayni; Naaser A. Y. Abduh

Publisher

MDPI AG

Published

2023

Language

EN

Field

Medicine (Life Sciences)