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Fast and Efficient Tritium Labelling of the Nonsteroidal Anti-inflammatory Drugs Naproxen, Tolmetin, and Zomepirac by Steen K. Johansen; Lone Sørensen; Lars Martiny is a Medicine article available to read on EtoBox.

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## Abstract Fast and efficient tritium labelling of the nonsteroidal anti‐inflammatory drugs naproxen, tolmetin and zomepirac is reported. Naproxen along with its (__R__)‐enantiomer were labelled by catalytic tritium–halogen exchange of the corresponding 5‐bromo derivatives providing [^3^H]naproxen with a specific activity of 25.4 Ci/mmol. Tolmetin and zomepirac were labelled by the hydrogen isotope exchange reaction using Crabtree's catalyst. This provided [^3^H]tolmetin and [^3^H]zomepirac with specific activities of 80.8 and 64.3 Ci/mmol, respectively. All compounds were obtained in high radiochemical purity (>98%). Copyright © 2005 John Wiley & Sons, Ltd.

Who reads Fast and Efficient Tritium Labelling of the Nonsteroidal Anti-inflammatory Drugs Naproxen, Tolmetin, and Zomepirac?

Author

Steen K. Johansen; Lone Sørensen; Lars Martiny

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

2005

Language

EN

Field

Medicine (Life Sciences)