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The clinical significance of MAGEA3 expression in pancreatic cancer by Joseph Kim; Howard A. Reber; Oscar J. Hines; Kevork K. Kazanjian; Andy Tran; Xing Ye; Farin F. Amersi; Steve R. Martinez; Sarah M. Dry; Anton J. Bilchik; Dave S.B. Hoon is a Medicine article available to read on EtoBox.
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## Abstract The MAGEA gene family that encodes cancer testis antigens is differentially expressed in many cancers. Though MAGEA3 expression has been detected in gastrointestinal malignancies, its role in pancreatic ductal adenocarcinoma (PDAC) has not been well established. We assessed 57 patients who underwent intent‐to‐cure surgery for PDAC. Total RNA from paraffin‐embedded pancreatic tumors was extracted and assessed for __MAGEA3__ gene expression by an optimized probe‐based quantitative real‐time RT‐PCR (qRT) assay. __MAGEA3__ gene expression was detected by qRT in 25 (44%) patients. For the entire cohort, detection of __MAGEA3__ expression was associated with significantly decreased overall survival (median, 16 __vs__ 33 months; log‐rank, __p__ = 0.032). When clinicopathologic factors, including age, gender, stage, tumor extent, lymph node metastasis, tumor grade, perineural invasion and lymphovascular invasion were assessed by univariate analysis, __MAGEA3__ gene expression and tumor grade were significant prognostic factors for poor survival (HR 2.1, 95% CI: 1.0–4.4, __p__ = 0.041; and HR 3.7, 95% CI: 1.8–7.6, __p__ = 0.0004, respectively). Immunohistochemistry (IHC) was per
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- Author
- Joseph Kim; Howard A. Reber; Oscar J. Hines; Kevork K. Kazanjian; Andy Tran; Xing Ye; Farin F. Amersi; Steve R. Martinez; Sarah M. Dry; Anton J. Bilchik; Dave S.B. Hoon
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)