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Multifaceted Role of Polyphenols in the Treatment and Management of Neurodegenerative Diseases by Fahadul Islam; Md Mohaimenul Islam; Atkia Farzana Khan Meem; Mohamed H. Nafady; Md Rezaul Islam; Aklima Akter; Saikat Mitra; Fahad A. Alhumaydhi; Talha Bin Emran; Ameer Khusro; Jesus Simal-Gandara; Aziz Eftekhari; Fatemeh Karimi; Mehdi Baghayeri is a Environmental Science article available to read on EtoBox.

What is Multifaceted Role of Polyphenols in the Treatment and Management of Neurodegenerative Diseases about?

Neurodegenerative diseases (NDDs) are conditions that cause neuron structure and/or function to deteriorate over time. Genetic alterations may be responsible for several NDDs. However, a multitude of physiological systems can trigger neurodegeneration. Several NDDs, such as Huntington's, Parkinson's, and Alzheimer's, are assigned to oxidative stress (OS). Low concentrations of reactive oxygen and nitrogen species are crucial for maintaining normal brain activities, as their increasing concentrations can promote neural apoptosis. OS-mediated neurodegeneration has been linked to several factors, including notable dysfunction of mitochondria, excitotoxicity, and Ca2+ stress. However, synthetic drugs are commonly utilized to treat most NDDs, and these treatments have been known to have side effects during treatment. According to providing empirical evidence, studies have discovered many occurring natural components in plants used to treat NDDs. Polyphenols are often safer and have lesser side effects. As, epigallocatechin-3-gallate, resveratrol, curcumin, quercetin, celastrol, berberine, genistein, and luteolin have p-values less than 0.05, so they are typically considered to be statis

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Author

Fahadul Islam; Md Mohaimenul Islam; Atkia Farzana Khan Meem; Mohamed H. Nafady; Md Rezaul Islam; Aklima Akter; Saikat Mitra; Fahad A. Alhumaydhi; Talha Bin Emran; Ameer Khusro; Jesus Simal-Gandara; Aziz Eftekhari; Fatemeh Karimi; Mehdi Baghayeri

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Environmental Science (Physical Sciences)