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CircRNA circ\_0000554 promotes ovarian cancer invasion and proliferation by regulating miR-567 by Hui Wang; Xuezhong Zhang; Lujun Qiao; Heng Wang is a scholarly article available to read on EtoBox.

What is CircRNA circ\_0000554 promotes ovarian cancer invasion and proliferation by regulating miR-567 about?

Circular RNAs (circRNAs) indicated potential modulating effects in tumor development. However, the specific role of circ\_0000554 in ovarian tumor remains unknown. We found that circ\_0000554 was overexpressed in ovarian tumor specimens and cells. Forced expression of circ\_0000554 promoted cell growth, invasion, and epithelial to mesenchymal transition (EMT). We illustrated that miR-567 was downregulated in ovarian tumor specimens and cells. circ\_0000554 was negatively correlated with miR-567 in ovarian tumor specimens. circ\_0000554 sponged miR-567 expression in ovarian tumor. RIP assay showed that elevated expression of miR-567 could be enriched with circ\_0000554. Luciferase reporter assay indicated that luciferase intensity was inhibited after treated with miR-567 mimic; however, the luciferase value of mut type was not decreased. Elevated expression of circ\_0000554 suppressed miR-567 expression in HO8910 cell. circ\_0000554 promoted ovarian tumor cell growth, invasion, and EMT via sponging miR-567. It suggested that circ\_0000554 represent a potential therapy target for ovarian tumor.

Author

Hui Wang; Xuezhong Zhang; Lujun Qiao; Heng Wang

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN