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Can I read HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data on EtoBox?

HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data by Perera, Chamila (author);Zhang, Haixiang (author);Zheng, Yinan (author);Hou, Lifang (author);Qu, Annie (author);Zheng, Cheng (author);Xie, Ke (author);Liu, Lei (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data about?

## Abstract Mediation analysis plays a major role in identifying significant mediators in the pathway between environmental exposures and health outcomes. With advanced data collection technology for large-scale studies, there has been growing research interest in developing methodology for high-dimensional mediation analysis. In this paper we present HIMA2, an extension of the HIMA method (Zhang in Bioinformatics 32:3150–3154, 2016). First, the proposed HIMA2 reduces the dimension of mediators to a manageable level based on the sure independence screening (SIS) method (Fan in J R Stat Soc Ser B 70:849–911, 2008). Second, a de-biased Lasso procedure is implemented for estimating regression parameters. Third, we use a multiple-testing procedure to accurately control the false discovery rate (FDR) when testing high-dimensional mediation hypotheses. We demonstrate its practical performance using Monte Carlo simulation studies and apply our method to identify DNA methylation markers which mediate the pathway from smoking to reduced lung function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Who reads HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Perera, Chamila (author);Zhang, Haixiang (author);Zheng, Yinan (author);Hou, Lifang (author);Qu, Annie (author);Zheng, Cheng (author);Xie, Ke (author);Liu, Lei (author)
Publisher
Springer Science and Business Media LLC
Published
2022
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Life Sciences)

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