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Inhibitory effect of the polyinosinic‐polycytidylic acid/cationic liposome on the progression of murine B16F10 melanoma by Taku Fujimura; Satoshi Nakagawa; Tomoyuki Ohtani; Yumiko Ito; Setsuya Aiba is a Immunology and Microbiology article available to read on EtoBox.

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## Abstract Cellular proteins, retinoic acid inducible gene‐I and Toll‐like receptor 3, sense dsRNA including polyinosinic‐polycytidylic acid (PIC) to stimulate innate immune response. The local administration of PIC has been demonstrated to be effective in anti‐tumor immunotherapy. However, the effects of PIC delivered cross the cell membrane have not yet been examined. To address this issue, we used a complex of PIC and cationic liposome (PIC liposome) and examined its anti‐tumor effects __in vitro__ and __in vivo__. PIC liposome could directly suppress the growth of B16F10 melanoma __in vitro__ and repeated peritumoral injections of PIC liposome inhibited melanoma growth in a dose‐dependent manner. This treatment induced tyrosinase‐related protein‐2 (TRP‐2)‐tetramer^+^ CD8^+^ cells in the lymph nodes. As the mechanism for its anti‐tumor immune response, we showed that the intradermal injection of PIC liposome induced the maturation of dendritic cells (DC). Moreover, the intratumoral injection of immature DC after treatment with PIC liposome significantly increased the number of TRP‐2‐specific IFN‐γ‐producing cells in the lymph nodes as well as spleen, which resulted in an augmen

Who reads Inhibitory effect of the polyinosinic‐polycytidylic acid/cationic liposome on the progression of murine B16F10 melanoma?

Author

Taku Fujimura; Satoshi Nakagawa; Tomoyuki Ohtani; Yumiko Ito; Setsuya Aiba

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

2006

Language

EN

Field

Immunology and Microbiology (Life Sciences)