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Can I read Modelling Bound Ligands in Protein Crystal Structures on EtoBox?
Modelling Bound Ligands in Protein Crystal Structures by P. H. Zwart; G. G. Langer; V. S. Lamzin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Modelling Bound Ligands in Protein Crystal Structures about?
Methods for automated identi®cation and building of proteinbound ligands in electron-density maps are described. An error model of the geometrical features of the molecular structure of a ligand based on a lattice distribution of positional parameters is obtained via simulation and is used for the construction of an approximate likelihood scoring function. This scoring function combined with a graph-based search technique provides a ̄exible model-building scheme and its application shows promising initial results. Several ligands with sizes ranging from 9 to 44 non-H atoms have been identi®ed in various X-ray structures and built in an automatic way using a minimal amount of prior stereochemical knowledge.
Who reads Modelling Bound Ligands in Protein Crystal Structures?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- P. H. Zwart; G. G. Langer; V. S. Lamzin
- Publisher
- International Union of Crystallography; Blackwell Publishing Inc.; International Union of Crystallography (IUCr) (ISSN 0907-4449)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)