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A Comparison of Human Papillomavirus Testing of Clinician‐collected and Self‐collected Samples During Follow‐up After Screen‐and‐treat by Sylvia Taylor; Chunhui Wang; Thomas C. Wright; Lynette Denny; Louise Kuhn is a Medicine article available to read on EtoBox.

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## Abstract Screen‐and‐treat cervical cancer prevention programs based on high‐risk human papillomavirus (HPV) testing and cryotherapy have been shown to be effective in resource‐limited settings. However, because cryotherapy is not 100% effective, follow‐up is needed after treatment to detect post‐treatment failures. We compared the test performances of high‐risk HPV testing (Hybrid Capture 2) using self‐collected and clinician‐collected samples as well as cervical cytology for identifying cervical intraepithelial neoplasia grades 2 or 3 or invasive cervical cancer (CIN2+) among women who did (__n__ = 812) and did not (__n__ = 1858) undergo cryotherapy in a South African screen‐and‐treat trial. At 6 months after enrolment (and after cryotherapy, if performed), women were tested using all three screening methods and then underwent colposcopy/biopsy. A predefined subset of women (__n__ = 1,455) had extended follow‐up with colposcopy/biopsy at 12 months. A total of 33 and 91 cases of CIN2+ were detected among treated and untreated women, respectively. The sensitivity of HPV testing using clinician‐collected samples and cervical cytology did not differ by treatment status. HPV testing

Who reads A Comparison of Human Papillomavirus Testing of Clinician‐collected and Self‐collected Samples During Follow‐up After Screen‐and‐treat?

Author

Sylvia Taylor; Chunhui Wang; Thomas C. Wright; Lynette Denny; Louise Kuhn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2011

Language

EN

Field

Medicine (Health Sciences)