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Can I read 146P The changing landscape of stage-at-presentation in lung cancer in the United States: Long-term data from SEER database on EtoBox?
146P The changing landscape of stage-at-presentation in lung cancer in the United States: Long-term data from SEER database by M. Mohamed Shawqi; M.B. Behery; M.I. Ewis; Y.M. El-Said; O.A. Aboshady; M.T. Khallafallah is a Medicine article available to read on EtoBox.
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Background: We have recently demonstrated that current heavy smokers with >20 pack-year (PY) smoking history (median, 48.8, IQR, 31.6-57.0 PY) and non-heavy smokers (<20 PY; median, 11.4; IQR, 7.3-14.4 PY) have about 40-and 10-times higher risk of lung cancer, respectively (JAMA-Oncol. 2022; 8:1428-1437). In the current study, we examined the magnitude of the graded risk increase associated with PY of smoking among current smokers. Methods: Of the 2505 community-dwelling older current smokers (mean age, 73 ± 5.7 years, 69% women, 17% African American) in the Cardiovascular Health Study (CHS), 1973 were never-smokers. The 532 current smokers were categorized based on PY smoking into: <20 (n = 95), 20-39 (n = 157), 40-59 (n = 181) and ≥60 (n = 94). Cause-specific HR (95% CI) for incident lung during 23 years of follow-up were estimated for the 4 groups (reference: never-smokers) based on Cox regression model, adjusting age, sex, race and competing risk of death. Results: Incident lung cancer occurred in 0.5% of never smokers, and 5.0%, 14.6%, 17.7% and 16.0% of those with <20, 20-39, 40-59, and ≥60 PY smoking history, respectively. Compared with never smokers, cause-specific HRs (95%
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- Author
- M. Mohamed Shawqi; M.B. Behery; M.I. Ewis; Y.M. El-Said; O.A. Aboshady; M.T. Khallafallah
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)